Case Report: Innate Immune System Challenge Unleashes Paraneoplastic Neurological Autoimmunity
نویسندگان
چکیده
منابع مشابه
Management of Immune-Mediated Paraneoplastic Neurological Disorders
Paraneoplastic neurological syndromes (PNS) are immune-mediated paraneoplastic disorders of the nervous system caused by tumor-induced disturbance of immune tolerance to neuronal antigens. Tumors expressing neuronal proteins, either intracellularly or on cell membranes, are most relevant (▶Table 1). The detection of antineuronal antibodies (Abs) confirms the diagnosis of PNS in patients present...
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Paraneoplastic neurological syndromes (PNS) are disorders of the nervous system that are associated with remote effects of malignancy. PNS are considered to have an autoimmune pathology. It has been suggested that immune antitumor responses are the origin of improved outcome in PNS. We describe cell-mediated immune responses in PNS and their potential contributions to antitumor reactions. Exper...
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Necrobiotic xanthogranuloma This presents as multiple sharply demarcated, indurated, non-tender dermal or subcutaneous nodules and plaques. Periorbital involvement is common. Lesions vary from violaceous to red orange, and enlarge to form infiltrative plaques that may show central atrophy. Though most of the lesions are asymptomatic, some may be pruritic or painful. Ulceration and scarring are ...
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Paraneoplastic neurological syndromes are immune-mediated erroneous attacks on the central or peripheral nervous systems, or both, directed originally against the tumour itself. They have been known for more than 40 years, but recently the discovery of new subgroups of paraneoplastic encephalitis syndromes with a remarkably good response to immune therapy has ignited new clinical and scientific...
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ژورنال
عنوان ژورنال: Frontiers in Neurology
سال: 2020
ISSN: 1664-2295
DOI: 10.3389/fneur.2020.598894